Dopamine antagonists

Dopamine antagonists are substances that bind to the dopamine D2 receptors in the anterior pituitary, thereby preventing dopamine from docking onto the receptors. If the receptors are not blocked, the binding of dopamine would start a signal cascade that inhibits the prolactin gene transcription and subsequently reduce prolactin synthesis. Therefore, dopamine antagonists are commonly used off-label as galactogogues (McGuire, 2018, La Torre & Falorni, 2007).