Silymarin

Silymarin is the bioactive compound of the milk thistle plant. High concentrations of the lipophilic substance can be found in the seeds of milk thistle fruits (Valková, 2020).

Silymarin has hepatoprotective, anticarcinogenic, antiinflammatory, immunomodulatory and potential neuroprotective activity. Additionally, it has been used as galactogogue (i.e., milk inducer) for centuries (Gazák et al., 2007, Valková, 2020, Xie et al., 2019).

Silymarin is composed of seven major flavonoligans, one flavonoid and several polyphenols (Valková, 2020, Gazák et al., 2007). It has poor bioavailability and likewise a low oral absorption rate. To increase silymarin water solubility and bioavailability phytosomes can be used that support its absorption, thus increase its bioavailability and subsequently increase its biological activity within the human body (Xie et al., 2019, Kidd, 2009).