Pregnancy Associated Plasma Protein-A

Pregnancy Associated Plasma Protein is produced by both the embryo and the placenta and is the largest of the pregnancy associated proteins. One of its functions is to protect the embryo from being recognized and rejected by maternal immune cells. Concentrations of this protein continue to rise in maternal blood from the beginning of pregnancy in the first trimester until term. If PAPP-A is detected in the first and second trimester, it indicates that the infant may have Down syndrome (Chasen, 2014, Hill, 2020).

Synonyms: PAPP-A