Secretory Immunoglobulin A

Secretory immunoglobulin A (sIgA) is an antibody, produced by plasma cells in the lamina propria, and secreted thorugh the intestinal epithelium into the mucus membrane. In the intestinal mucous sIgA neutralizes foreign molecules and pathogens thereby contributing to the protection of the intestinal epithelium. sIgA can neutralize pathogens by binding to their adhesion molecules, which subsequently cannot attach to epithelial cells. Moreover, sIgA marks pathogens for the complement system and immune cells for elimination (Corthésy, 2010).