Ferritin

Ferritin is an intracellular iron storage protein. When cellular iron concentrations increase, the expression of ferritin is upregulated to sequester unbound iron to circumvent oxidative damages. Therefore, serum ferritin levels (excreted from the cells) can be used as an indicator of body iron stores and iron overloading (Wallace, 2016, Anderson & Frazer, 2017). However, serum ferritin concentrations can be affected by pathologies independent of iron status, such as during inflammation (Imam et al., 2017).