Human milk oligosaccharide terminology


text justify

Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.   

Duis autem vel eum iriure dolor in hendrerit in vulputate velit esse molestie consequat, vel illum dolore eu feugiat nulla facilisis at vero eros et accumsan et iusto odio dignissim qui blandit praesent luptatum zzril delenit augue duis dolore te feugait nulla facilisi. Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh euismod tincidunt ut laoreet dolore magna aliquam erat volutpat.   

Ut wisi enim ad minim veniam, quis nostrud exerci tation ullamcorper suscipit lobortis nisl ut aliquip ex ea commodo consequat. Duis autem vel eum iriure dolor in hendrerit in vulputate velit esse molestie consequat, vel illum dolore eu feugiat nulla facilisis at vero eros et accumsan et iusto odio dignissim qui blandit praesent luptatum zzril delenit augue duis dolore te feugait nulla facilisi.  

Human milk oligosaccharides


And subheader

Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua.

Text with image

Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.

At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, At accusam

Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.

At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, At accusam 

(copy 2)


Text with image

Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.

At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo

(copy 1)


Text with image

Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.

At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo

(copy 3)


Text with image

Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.

At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, At accusam aliquyam diam diam dolore dolores duo eirmod eos erat, et nonumy sed tempor et et invidunt justo labore Stet clita ea et gubergren, kasd magna no rebum. sanctus sea sed takimata ut vero voluptua. est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur

At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, At accusam aliquyam diam diam dolore dolores duo eirmod eos erat, et nonumy sed tempor et et invidunt justo labore Stet clita ea et gubergren, kasd magna no rebum. sanctus sea sed takimata ut vero voluptua. est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur

Nam liber tempor cum soluta nobis eleifend option congue nihil imperdiet doming id quod mazim placerat facer possim assum. Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh euismod tincidunt ut laoreet dolore magna aliquam erat volutpat. Ut wisi enim ad minim veniam, quis nostrud exerci tation ullamcorper suscipit lobortis nisl ut aliquip ex ea commodo consequat.   

Duis autem vel eum iriure dolor in hendrerit in vulputate velit esse molestie consequat, vel illum dolore eu feugiat nulla facilisis.   

At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, At accusam aliquyam diam diam dolore dolores duo eirmod eos erat, et nonumy sed tempor et et invidunt justo labore Stet clita ea et gubergren, kasd magna no rebum. sanctus sea sed takimata ut vero voluptua. est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur

Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.

Lorem ipsum dolor


Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.

Download


lorem impsum dolor ...
sit amet, consetetur sadipscing elitr
sed diam nonumy eirmod

test test
tetstettste 

Download


lorem impsum dolor ...
sit amet, consetetur sadipscing elitr
sed diam nonumy eirmod

Downloads


Breastfeeding-Fact-1.jpg download 54 KB / jpg
logo.png download 43 KB / png
Breastfeeding-Facts-HERO.jpg download 92 KB / jpg
breastfeeding-tips-infographic.pdf
breastfeeding-tips-infographic.pdf download 640 KB / pdf
natural-helpers-infant-digestion-table.pdf
natural-helpers-infant-digestion-table.pdf download 150 KB / pdf
breastfeeding-benefits-infographic.pdf
breastfeeding-benefits-infographic.pdf download 470 KB / pdf

1080x1080


Videoeinbindung per Youtube Links


Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit am

Test inDetail link


Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet.
see more

  • Prebiotics test



    Gibson et al.. 2017. Nat Rev Gastroenterol Hepatol 14(8), 491–502

    More information is available here.

    back
  • Structural diversity – Human milk oligosaccharides can be categorised by their residues (test)


    ##Human milk oligosaccharides## structures are described by a basic blueprint ##Figure 3##: Lactose is a core component linked with at least one further residue or unit. Based on the presence of these residues, HMO can be sorted into three different ##categories##:

    1. Fucosylated HMO (##Figure 7##) are linked with at least one L-fucose residue.
    2. Sialylated or acidic HMO (##Figure 8##) are oligosaccharides linked with at least one sialic acid residue.

    Non-fucosylated or neutral HMO (##Figure 9##) are linked with at least one galactose, N‑acetyllactosamine, or lacto‑N‑biose unit. They are neither linked with fucose nor sialic acid (Ayechu-Muruzabal et al. 2018; Kunz et al. 2000).


    back
  • Structural diversity – Human milk oligosaccharide building blocks (test)


    All ##human milk oligosaccharides## (HMO) can be described with an equation such as this:

    To break down this complicated seeming equation, we start with the three to five monosaccharides or monomers that are the building blocks of HMO (##Figure 3##). Depending on the way these five building blocks are combined together with a number of different structural ways to connect, they form more than 200 HMO isoforms (Thurl et al. 2010).

    The disaccharide ##lactose## is a combination of D‑glucose (Glu, blue circle ##Figures 3## and ##4##) with D-galactose (Gal, yellow hexagon, ##Figures 3## and##4## yellow hexagon) connected via a β1-4 bond (##Figure 5##). As free disaccharide or dimer, lactose is the major carbohydrate in mother's milk and thus called milk sugar. Lactose is a core component of all HMO isoforms: It is located at the terminal end of all HMO and further modified by the addition of D-galactose , N‑acetyllactosamine, fucose, or sialic acid, elongated and branched in various ways to form the multitude of known HMO isoforms (##Figure 4##) (Bode. 2012, 2006).

    The type of connection ‑ that is the glucoside bond ‑ plays a crucial role in HMO formation. It can define the 3D structure, thus determine interaction of the HMO to microorganisms (##decoy receptor##) or access of enzymes and other metabolites, and therefore affect functionality of the HMO isoform that was synthesised.

    back
  • Test Table

  • Test Table 2


    Table 412- 2 Maximum concentrations of isolated human milk oligosaccharides allowed as per European Commission.

     

    Products for infants younger than 12 months

    Baby food for infants and young children

     

     

    Infant
    formula[1]

    Follow-on formula

    Processed cereal-based food

    Milk-based drinks or similar

    Safety evaluation by EFSA

    Age range1

    0-6 months

    6-12 months

    6 - ≤ 36 months

     

    HMO isoform and EU legislation implementing the respective HMO as novel food in Europe

     

     

     

     

    2'‑fucosyllactose

    (EU/2016/375; EU/2017/2470; EU/2019/1979)

    1.2 g/l alone

    or in combination with lacto-N-neotetraose;

    1.6 g/l as specific mix with difucosyllactose

    1.2 g/l alone or in combination with lacto-N-neotetraose;

    1.2 g/l as specific mix with difucosyllactose

    12 g/kg for products other than beverages alone or 10 g/kg as specific mix with difucosyllactose;

    1.2 g/l for liquid food ready to use alone or as specific mix with difucosyllactose

    1.2 g/l alone, in a specific mix with difucosyllactose or at a 2:1 ratio with lacto-N-neotetraose

    (EFSA NDA. 2015a)

    Lacto‑N‑neotetraose

    (EU/2016/375; EU/2017/2470)

    -

    -

    6 g/kg for products other than beverages; 0.6 g/l for liquid food ready to use;

    0.6 g/l

    (EFSA NDA. 2015b, 2015c)

    Mix lacto‑N‑neotetraose + 2'‑fucosyllactose

    (EU/2016/375; EU/2017/2470)

    0.6 g/l in combination with 1.2 g/l of 2'‑fucosyllactose at a ratio of 1:2

    0.6 g/l in combination with 1.2 g/l of 2'‑fucosyllactose at a ratio of 1:2

    6 g/kg for products other than beverages;

    0.6 g/l for liquid foods

    0.6 g/l in combination with 2'FL at a ratio of 1:2 in the final product

    (EFSA NDA. 2015b)

    Difucosyllactose

    (EU/2019/1979)

    -

    -

    -

    -

     

    Mix difucosyllactose + 2'‑fucosyllactose[2]

    (EU/2019/1979)

    1.6 g/l of the mixture

    1.2 g/l of the mixture

    1.2 g/l (beverages)

    10 g/kg for products other than beverages

    1.2 g/l (beverages)

    10 g/kg for products other than beverages

    (EFSA NDA. 2019a)

    Lacto‑N‑tetraose

    (EU/2020/484)

    0.8 g/l

    0.6 g/l

    0.6 g/l (beverages)

    5 g/kg for products other than beverages

    0.6 g/l (beverages)

    5 g/kg for products other than beverages

    (EFSA NDA et al. 2019b)

    3'‑sialyllactose[3],[4]

     

    0.2 g/l

    0.15 g/l

    0.15 g/l in a ready to feed product ;

    1.25 g/kg for products other than beverages

    0.15 g/l in a ready to feed product;

    1.25 g/kg for products other than beverages

    (EFSA NDA. 2020a)

    6'-sialyllactose2,3

     

    0.4 g/l

    0.3 g/l

    0.3 g/l in a ready to feed product;

    2.5 g/kg for products other than beverages

    0.3 g/l in a ready to feed product;

    2.5 g/kg for products other than beverages

    (EFSA NDA. 2020b)

    3'-galactosyllactose

    -

    -

    -

    -

    -

    -

     


    [1] Age range and product descriptions as per Regulation EU/2013/609 .

    [2] Mix contains ³ 75% 2'FL and ³ 5% DiFL (w/w in % of dry matter) EU/2019/1979 .

    [3] Novel food applications for 3'SL and 6'SL have been submitted to the European Commission beginning 2019 [https://ec.europa.eu/food/safety/novel_food/authorisations/summary-applications-and-notifications_en]

    [4] Values proposed by EFSA

    back